
Can I give ampicillin to my dog? Ampicillin is an antibiotic that has been used in humans and other animals to treat bacterial infections.
Certain infections in dogs are treated with ampicillin, including upper respiratory infections (such as pneumonia), urinary tract infections, skin infections, soft tissue infections, gastroenteritis, tonsillitis, salmonella, canine parvovirus, and leptospirosis.
It can also be used to prevent infections before, during, and after invasive surgical or dental procedures.
What dosage of ampicillin should I give my dog?
Ampicillin for dogs is available in capsules and tablets, as well as a liquid oral suspension and intramuscular (IM) or subcutaneous (SC) injections.
Veterinarians may occasionally administer intravenous (IV) medications, but they are rarely administered at home.
The dosage may differ depending on the form used. As a general rule of thumb:
- Oral solution, capsules, and tablets: 2 – 4 times daily, 10 – 25 mg/kg body weight
- 5 – 10 mg/kg bw IM, IV, and SC injections 2 – 3 times daily
Higher doses may be given for infections caused by resistant bacteria, certain infections (such as parvovirus), or infections of the central nervous system.
Dosage Guidelines for Ampicillin in Dogs
Ampicillin for dogs should be administered exactly as directed by your veterinarian.
Give your dog ampicillin 2 to 4 times daily on an empty stomach, 1 to 2 hours before meals if taking capsules, tablets, or oral solution.
If your dog vomits, combine the next dose with a small amount of food or a treat. Before measuring each dose, thoroughly shake the liquid.
Ampicillin is administered twice a day by injection into the muscle or subcutaneously.
Always use fresh needles and syringes, and properly dispose of them after each treatment.
Avoid injecting the drug into a vein, as this could be fatal. Your veterinarian’s IV medication may be of a different formulation.
Is ampicillin effective in dogs?

Ampicillin has been shown to be effective against a variety of bacteria that can infect dogs, including Staph, Clostridium, Bacillus anthracis, E. coli, Salmonella, and Pasteurella strains.
A study on the efficacy of ampicillin in treating gastrointestinal infections in dogs discovered a cure rate of 70%.
What are the risks of taking ampicillin?
Although ampicillin side effects are uncommon, they may include:
- Anorexia
- Discomfort at the injection site
- Vomit
- Diarrhea
When dogs are given higher doses of ampicillin, they may experience more serious side effects, which may include:
- Combination
- Increased respiration
- Raise your heart rate
- Swelling
When the medication is taken with food, it can reduce some digestive side effects.
When ampicillin is stopped, the effects should wear off within 24 hours, but they may last longer in dogs with renal or hepatic disease.
Dos and Don’ts When Giving Ampicillin to Your Dog
Ampicillin should not be given to dogs who are allergic to any penicillin antibiotic.
In dogs with kidney or heart disease, or in dogs who are dehydrated, this medication should be used with caution.
Despite the fact that current research shows no evidence of adverse effects in pregnant or lactating dogs.
In these cases, ampicillin should also be used with caution.
Ampicillin hypersensitivity and allergic reactions

Allergic reactions and sensitivities to ampicillin are uncommon, but they can manifest in a variety of ways.
Stop using ampicillin immediately if your dog develops irregular breathing, fever, rash, hives, or swelling in the face or other areas.
Excessive drooling, diarrhea, vomiting, a rapid heart rate, and seizures are all symptoms of an allergic reaction.
Ampicillin Frequently Asked Questions
What if I forget to take a dose?
If you forget to give your dog an ampicillin dose, give it to him as soon as you remember.
If your next dose is approaching, skip the missed dose and take your regular dose. Never give a dog two doses of ampicillin, either orally or intravenously.
Is it necessary for my veterinarian to monitor my dog while he is taking ampicillin?
Unless your dog has heart, liver, or kidney disease, no special monitoring is required while taking ampicillin.
Your veterinarian can check on your dog to ensure that the medication is effective.
Ampicillin use may result in false positives in some urine glucose tests.
What should you do in an emergency?
If you suspect your dog is suffering from an allergic reaction or has overdosed, contact your veterinarian or an emergency veterinary hospital right away.
Vomiting, weakness, disorientation, increased excretion and thirst, pale mucous membranes, coma, and convulsions are all symptoms of an overdose.
What is the best way to store ampicillin?
The capsules, tablets, and powder of ampicillin oral suspension can be stored at room temperature (59°F to 86°F).
The liquid oral mixture can be stored at room temperature for 7 days or chilled for 14 days.
Anyone who is allergic to penicillin or beta-lactam antibiotics should avoid using this medication because anaphylaxis may occur.
Most importantly, giving ampicillin to dogs should only be done under the supervision of a veterinarian. The above article is provided for informational purposes only and is not intended to replace the advice of a veterinarian.
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